Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test
نویسندگان
چکیده
منابع مشابه
Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test.
BACKGROUND Zinc is an important trace element essential for numerous bodily functions. It is believed that a deficiency of zinc can lead to various conditions, including depression, on which this study is focused. It is still not known if hypozincemia leads to the development of depression or whether zinc deficiency is a result of depression. It is hypothesized that zinc may be a therapeutic ag...
متن کاملPharmacokinetic interaction after joint administration of zinc and imipramine in forced swim test in mice.
Recent preclinical and clinical data indicate beneficial role of zinc in the antidepressant treatment. To evaluate the mechanism of interaction between zinc and antidepressants, in the present study we examined the brain zinc, imipramine and desipramine concentrations in mice treated with combinations of zinc and imipramine and subjected to the forced swim test. We have chosen doses of zinc (10...
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15 صفحه اولThe mouse forced swim test.
The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states. Mice are placed in an inescapable transparent tank that is filled with water and their escape related mobility behavior is measured. The forced swim test is straigh...
متن کاملThe Effects of Dopamine Receptor Agents on Swim Stress-Induced Inhibition of Naloxone-Induced Jumping Behavior in Morphine-Dependent Mice
In the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (WSS) on naloxone-induced jumping in morphine-dependent mice were examined. Mice were rendered dependent as described in the methods section. The opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). The first group exposed to WSS in the pr...
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ژورنال
عنوان ژورنال: Pharmacological Reports
سال: 2012
ISSN: 1734-1140
DOI: 10.1016/s1734-1140(12)70852-6